The story takes place in Togenkyo, where humans and yokai coexisted peacefully until a group attempted to revive Gyumaoh, a powerful yokai killed by the war god Nataku Taishi 500 years ago. The failed experiment, combining chemistry and magic, caused chaos as yokai turned violent and attacked humans. In response, Kanzeon bosatsu sends Son Goku, Genjyo Sazno, Sha Gojyo, and Cho Hakkai on a mission to stop the revival and restore balance.