Saving 80,000 Gold in Another World for My Retirement follows the story of Mitsuha Yamano, who's forced to start anew after a series of unfortunate events, including failing to enter her preferred university and experiencing a family tragedy. After a near-death experience, Mitsuha is transported to another world, where she initially struggles to survive. She eventually meets Colette, a young girl who helps her, and subsequently gains divine knowledge about her new abilities, including superhuman regeneration and interworld travel. With this power, Mitsuha sets a goal to save 80,000 gold coins to ensure a secure retirement.